TMA Foresight is a tool designed to explore the relatedness of prognostic marker expression and clinico-pathological variates with the outcome. It identifies important prognostic markers that influence the outcome and identifies prognostically significant clusters of patients. Based on the data provided, it helps decide the risk group of a cohort. TMA Foresight uses well established statistical techniques to interpret the results of a TMA experiment, making it a useful tool for pathologists, clinicians and researchers.
Easy Data Preprocessing
TMA Foresight allows the data to
be categorized, replaced or
ignored from a single screen. It
helps map character data to
numeric values with a click of a
button. Missing data can be easily filled up depending on
the measurement level chosen, ensuring completeness of
data for further analysis. You can then apply multivariate
statistical techniques to identify prognostically significant
markers and clinico-pathological parameters that have a
significant impact on the outcome.
Statistical Tests
TMA Foresight has the ability to rapidly perform various statistical tests such as Cox proportional hazard model to identify prognostic markers, Kaplan-Meier survival plots to visualize the
survival/recurrence rates for a cohort and hierarchical clustering and Principal Component
Analysis to group patients into relatively homogeneous sub-groups based on a set of variables.
TMA Foresight has excellent point-and- click wizards making it easy to use for beginners, while
the versatile functionality offers full control for experts. For hierarchical clustering, TMA Foresight
enables you to move the linkage bar over the dendrogram which updates the Kaplan Meier plot
and the log rank test results accordingly. Similarly, for Principal Component Analysis, TMA
Foresight enables you to move an axis across the scatter plot generated between two variables,
to cluster patients. This functionality helps in determining prognostically significant clusters and
identifying high and low risk groups patients within a cohort. To explore linear, monotonic,
curvilinear, non-linear relationships between two covariates use bivariate correlation analysis. To
measure the correlation between any two variables by negating the influence of other variables
use the partial analysis. To study the likelihood of any two categorical variables being associated
use Fisher's Exact and Chi-square tests. TMA Foresight also counts the frequency, calculates the
mean, standard deviation and displays the range of different parameters. The information helps
in quick identification of any abnormalities within the data.
Strumento completo progettato per la ricerca di agenti patogeni, identificazione di batteri, identificazioni di speci (per Win & Mac)
For fast and efficient design of specific oligos for whole genome arrays, tiling arrays and resequencing arrays (per Win & Linux)
Design oligos for all major qPCR assays for robust amplification and fluorescence in real time PCR (per Win & Mac)
A unique design tool for xMAP® based multiplex systems (per Win & Mac)
A comprehensive primer design tool (per Win)
Glycan mass spectrometry identification tool (per Win)
A tool for drawing publication, vector catalog quality maps and designing cloning experiments (per Win & Mac)
A statistical tool for tissue microarray data analysis (per Win)
A novel tagged primer design tool for expression cloning and for designing sequencing primers to verify the transcripts (per Win & Mac)
Questi sono altri prodotti sviluppati dal fornitore del prodotto TMA Foresight.
AlleleID® designs probes and primers for pathogen detection, bacterial identification, species identification and taxa discrimination using qPCR assays and microarrays. It aligns sequences to locate differences in DNA and to find conserved regions. It then proceeds to design oligos to amplify and detect only the species or strains of interest from the mix. To design taxa/cross species assays, AlleleID designs the fewest number of oligos possible, resulting in cost savings. AlleleID supports assays for selectively amplifying cDNA from gDNA and designs oligos to detect splice variants by designing across intron/exon junctions. In addition, it designs probes for MLPA® assays and for PamGene's PamChip® microarrays to detect mutations and copy number changes. (per Win & Mac)
Array Designer is a comprehensive desktop tool to efficiently design hundreds of specific oligos for SNP detection or expression studies or hundreds of PCR primer pairs for cDNA microarrays in seconds. It can automatically design whole genome, tiling, and resequencing arrays. All probes are checked for specificity by using BLAST to identify regions of cross homology and automatically avoiding these areas. (per Win & Linux)
Beacon Designer designs oligos for SYBR® Green, TaqMan®, LNA spiked TaqMan®, MethyLight, molecular beacon, NASBA®, Scorpions® and FRET assays. Highly specific primers are designed by avoiding cross homologies found by automatically interpreting BLAST search results. The program ensures efficient hybridization and high yield by avoiding template secondary structures. Beacon Designer evaluates pre-designed assays and designs compatible oligos to extend the designs. It also designs beacons and TaqMan® for single tube multiplex experiments. (per Win & Mac)
Primer Premier is a program for PCR, hybridization, sequencing, nested and multiplex primer design. It uses ClustalW multiple sequence alignment to design cross species primers automatically in regions of low degeneracy. Primer Premier reverse translates amino acid sequences to design degenerate primers. Designing allele specific primers and primers for site-directed mutagenesis is made easy. Sequences can be analyzed for restriction enzymes and motifs using extensive built-in databases. (per Win)
PrimerPlex designs specific capture probes for direct hybridization assays and primers for Allele Specific PCR Extension (ASPE), for multiplexed SNP genotyping applications. The oligos are designed after avoiding the regions of homology identified by a BLAST search and are screened for cross homologies to ensure high signal strength. (per Win & Mac)
SimGlycan™ predicts the structure of a glycan from the MS/MS data acquired by mass spectrometry, facilitating glycosylation and post translational modification studies. SimGlycan™ accepts the experimental MS profiles generated by a mass spectrometer, matches them with its own database of theoretical fragmentation of over 8,000 glycans and generates a list of probable glycan structures. Each structure is scored to reflect how closely it matches your experimental data. Other biological information for the probable glycan structures such as the glycan class, reaction, pathway and enzyme are also made available for easy reference. (per Win)
SimVector is a web savvy program equipped with all the drawing tools necessary to publish engineered plasmid catalogs, as well as to simulate and draw plasmid constructs for Gateway®, TA, restriction or other popular cloning techniques. Export images in vector graphic format to produce the highest quality images for presentations in MS PowerPoint or publication in journals or vector catalogs using Adobe Illustrator. Alternatively, choose popular bitmap formats or export in ready-to-host web pages. With its powerful drawing features, it is easy to enhance vector maps with patterns, colors, fills, curved text and annotations. (per Win)
Xpression Primer is a web savvy Windows and Mac program with a sophisticated algorithm for designing optimal tagged primers to amplify ORFs for expression cloning systems. It provides comprehensive support for popular systems such as Gateway®, BD In-Fusion™, epitope and TOPO® tools. The program is flexible enough to work with virtually any expression system of researcher's choice. Xpression Primer also designs optimal sequencing primers to verify the transcripts.
